Mainly contributing to WP1 and WP2 and supporting WP3 and WP7.
HKU takes part in tasks related to the determination of SetTox and ToxScore values to be used in the validation of the lead demonstrator in WP1; the development of screening platforms for cytotoxicity determination of nanomaterials prepared using the flow system; and the realisation of a real-time computer-aided simulation package to determine the cytotoxicity of leached chemicals from as-prepared nanomaterials using first-principle calculations.
The Department of Chemistry at HKU has existing state-of-the-art instruments and personnel to develop computational techniques to predict nanoparticle properties and in situ spectroscopic techniques to analyse nanoparticle attributes. HKU also has strong ties with a neighbouring public hospital (Queen Mary Hospital) via the Faculty of Medicine and the School of Biological Sciences. The Centre for Genomic and Proteomic studies can provide support for molecular, cellular, and genetic toxicology studies. The Department of Chemistry can carry out in vitro cell culture, comet, MTT, ELISA assays, and related cytotoxicity studies. Various healthy and disease model cell lines are available. HKU possesses various optical, fluorescence, confocal, and light sheet microscopes. Students in the Tse group also have access to the TEM facility in HKU. The Department of Chemistry also possesses various computational clusters for in-house first-principle calculations for prediction of toxicity and properties of as-synthesized nanomaterials using a flow system.