Mainly contributing to WP5.
As an international partner, KRICT will contribute to WP5 for the development of predictive nanoQSAR models and toxicokinetic models; and to design of experiments for the collection of data suitable for modelling described in WP5.
The main tasks of KRICT will be as follows:
1. Investigation of the applicability of conventional additive toxicity models to the prediction of toxicity of mixtures containing nanomaterials (nano-mixtures);
2. Development of predictive nano-mixture QSAR models for estimating the nano-mixture toxicity; and,
3. Design of experiments for the collection of data suitable for modelling on the nano-mixture toxicity.
Expected deliverables of KRICT will be the investigation result of the applicability of conventional additive toxicity models to the prediction of nano-mixture toxicity; and more reliable nano-mixture QSAR models.
KRICT will act as an international partner and join WP5. Chemical Safety Research Center at KRICT has infrastructure for conducting computational toxicology research on the safety of nanomaterials with expertise in mixture toxicity prediction. Chemical Analysis Center at KRICT has significant infrastructure to characterising physico-chemical properties of nanomaterials with different analytical instruments (500/700 MHz NMRs, combustion IC, cryo-/FE-SEM, Raman spectrometer, elemental analyser, ED-XRF, HR/HT-XRD, ICP-MS, MALDI-TOF-MS, particle analyser, etc. Drug Discovery Platform Research Center at KRICT has lab infrastructure to carry out in vitro (eco)toxicity assessments with the automated HTS system and the zebrafish assay.