1. To model all SbD protocols using the systems control and optimisation protocol with the MPC concept. To underwrite the new platform technologies with in silico modelling procedures which use data from screening and release studies to redesign the production process. In silico technology is already developed in nanosafety, and this objective aims to combine the in silico with the experimental technology to give a single platform in the production line.

2. To design high throughput platform technologies which progress from TRL4 to 6 moving from the lab to the pilot line to apply the principles of SbD in the production of novel materials. The technologies at the lab level are designed according to a modelling protocol where results from high throughput screening and release studies feed back into the production line to manufacture NM with lower toxicity without impeding function. Screens will use an online platform with in vitro targets of increasing complexity from the 2D biomembrane to multiple cell-line and in vitro targets developed in current H2020 projects HISENTS and PATROLS respectively.

3. To design innovative technology to carry out short and long term release studies on NM and NM derived materials matching the theme of online flow through platforms.

4. To develop SbD technologies within the context of four specific industrial case studies involving the production, use and function of engineered nanomaterials (NM). These four case studies (CS) are:

Case Study 1: Coupling the HISENTS biomembrane screening model and other screening technologies direct to CuO and Ag production facilities to enable safe NM at output (Applied Nanoparticles SL);

Case Study 2: Production of chitosan-silicate coatings6 on in situ titanium dental implants. Release studies and high throughput in vitro screening results to feed back to and moderate implant production (RESCOLL);

Case Study 3: Electroplating of Ni / SiC and TiO2 composite coatings. Closed circuit electrolyte recirculation systems to allow electrolyte screening. Release studies on finished coating: results to feed back to coating formulation and production (Creative Nano PC); and,

Case Study 4: Flow-through synthesis of TiO2 NM (Nanotechcenter LLC).

5. To redesign the production lines in CS3 to an online high throughput mode to speed up the production process, to minimise volumes used, to lower costs and minimise waste contributing to a circular economy.

6. To maintain continuing communication with regulators and management, ensuring that SbD procedures are compliant and feed back to governance decisions within the aegis of the Stage-Gate process.

Overall strategy of SABYDOMA